DRUG DISCOVERY WITH CELL TARGET ENGAGEMENT

Choose any target class: 

• Enzymes
• Transcription factors
• Regulatory proteins
• Membrane proteins
• Other challenging targets 

Testing of challenging protein targets such as membrane bound proteins, transcription factors or organelle proteins is enabled by virtue of unique MICRO-TAG chemistry. 

Rank your hits: 

• Emax - dose of a drug at which the protein target is saturated by the drug to give maximum signal

• EC50 - potency of cell target engagement 

• KD - cellular target affinity constant 

Quantification of drug candidates during primary or secondary screen can not only identify speed up lead discovery, but also efficiently connect drug discovery to preclinical data. 

Work with any therapeutic modality:

• Small-molecules (allosteric and not) 

• PROTACS
• Peptides
• Antibodies

The MICRO-TAG system works well for discovery and testing of various drug candidates. 

Get mechanistic insight in the cell: 

• Real-time analysis of cell target engagement

• Real-time microscopy 

• Other novel applications 

Beside valuable mechanistic insight into the drug- target pairs and their binding stoichiometry, various cellular applications are enabled. lead discovery drug discovery