Validating engagement of drug candidates with therapeutic targets is a challenge in drug discovery. MICRO-TAG is the 3rd generation of cell target engagement technology. It enables interrogation of target engagement without interfering with folding, localization, and function of target proteins, all within the physiological milieu of the cell. Enable fast path to lead discovery with Nerd Bio's cell target engagement platform.
Choose any target class:
• Transcription factors
• Regulatory proteins
• Membrane proteins
• Other challenging targets
Testing of challenging protein targets such as membrane bound proteins, transcription factors or organelle proteins is enabled by virtue of unique MICRO-TAG chemistry.
Rank your hits:
• Emax - dose of a drug at which the protein target is saturated by the drug to give maximum signal
• EC50 - potency of cell target engagement
• KD - cellular target affinity constant
Quantification of drug candidates during primary or secondary screen can not only identify speed up lead discovery, but also efficiently connect drug discovery to preclinical data.
Work with any therapeutic modality:
• Small-molecules (allosteric and not)
The MICRO-TAG system works well for discovery and testing of various drug candidates.
Get mechanistic insight in the cell:
• Real-time analysis of cell target engagement
• Real-time microscopy
• Other novel applications
Beside valuable mechanistic insight into the drug- target pairs and their binding stoichiometry, various cellular applications are enabled. lead discovery drug discovery